Investigating inactive conformations of protein kinases
نویسندگان
چکیده
منابع مشابه
Predicting Inactive Conformations of Protein Kinases Using Active Structures: Conformational Selection of Type-II Inhibitors
Protein kinases have been found to possess two characteristic conformations in their activation-loops: the active DFG-in conformation and the inactive DFG-out conformation. Recently, it has been very interesting to develop type-II inhibitors which target the DFG-out conformation and are more specific than the type-I inhibitors binding to the active DFG-in conformation. However, solving crystal ...
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lytic groups and relief of steric blocking to allow access Protein kinases and phosphatases play pivotal roles in of substrates to the catalytic site. The activation segregulating and coordinating aspects of metabolism, ment and the control of its conformation via phosphorygene expression, cell growth, cell motility, cell differentilation plays a key role in these transformations. It can ation,...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2013
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.27.1_supplement.1042.1